Correlation of beta-catenin and p53 Protein Expression with Clinico-pathologic Characteristics of Colorectal Cancer.
- Author:
Kil Min MOON
1
;
Young Jin PARK
;
Han Seung KIM
;
Seung Hae PARK
;
Ji Il KIM
;
Ki Hong KIM
;
Byung Joo SONG
;
Meung Soo LEE
;
Chul Nam KIM
;
Seok Hyo CHANG
Author Information
1. Department of Surgery, Ilsan-Paik Hospital, College of Medicine, Inje University, Goyang, Korea. yjpark@ilsanpaik.ac.kr
- Publication Type:Original Article
- Keywords:
Colorectal cancer;
beta-catenin;
p53;
Lymph node metastasis;
Differentiation
- MeSH:
beta Catenin*;
Carcinogenesis;
Colon;
Colonic Neoplasms;
Colorectal Neoplasms*;
Humans;
Lymph Nodes;
Lymphatic Metastasis;
Negative Staining;
Neoplasm Metastasis;
Prognosis
- From:Journal of the Korean Society of Coloproctology
2002;18(5):311-316
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Both the beta-catenin and p53 play a crucial role in the process of colon carcinogenesis. The expression of beta-catenin and/or p53 has been reported to be associated with pathologic features of tumor and prognosis of patients. In addition, several recent studies have suggested a close biological association between p53 expression and nuclear beta-catenin level. We analyzed the pathologic variables and p53 expression according to the intra-nuclear beta-catenin expression in colon cancer to make such assumptions more clear since they are still controversial issues. METHODS: The expressions of beta-catenin, p53 and Ki-67 protein in colon cancer were determined by immunohistochemical staining. The relationship between these protein expressions and tumor characteristics was statistically analyzed. RESULTS: The intra-nuclear beta-catenin accumulation was not associated with any of the pathological variables including lymph node metastasis and tumor differentiation, but it was correlated with higher level of Ki-67 proliferation index (P=0.006) and negative staining of p53 (P=0.015). Positive p53 staining was significantly associated with lymph node metastasis (P=0.006), lymphatic invasion (P=0.03) and venous invasion (P=0.02). CONCLUSION: These results support the suggestion that intra-nuclear accumulation of beta-catenin may regulate the p53 activity in colorectal cancer. In addition, positive staining of p53 may be used as a valuable prognostic indicator since it was strongly associated with lymph node metastasis, lymphatic and venous invasion.
