Approach to the pathogenesis of nonalcoholic fatty liver disease for early diagnosis and treatment of metabolic disorders

VernacularTitle:提高对非酒精性脂肪性肝病的认识,早期防治代谢紊乱
Author: Xin GAO
Publication Type:Journal Article
Keywords: Nonalcoholic fatty liver; Metabolic syndrome; Diabetes mellitus,type 2; Cardiovascular disease
From: Chinese Journal of Endocrinology and Metabolism 2010;26(7):529-530
CountryChina
Language:Chinese
Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder, affecting 10%-24% of the general population, and the incidence is much higher (70% -80% ) in type 2 diabetic patients. Recent studies indicate that fatty liver is an emerging problem in the Asia-Pacific region and China. The community prevalence of NAFLD in Shanghai is 15%. A large body of evidences suggests that NAFLD is the hepatic manifestation of the metabolic syndrome. NAFLD is not only associated with the metabolic syndrome, it also predicts the development of type 2 diabetes and cardiovascular disease (CVD). The liver is a central organ for controlling and regulating glucose and lipids metabolism; intrahepatocellular lipid accumulation plays a key role in the development of metabolic-ally related disorders. It is crucial that specialists, especially endocrinologists, and practising clinicians should be aware of the strong association between NAFLD and increased risks of diabetes and CVD, NAFLD should be diagnosed correctly and defined timely in regarding its role as risk factors of underlying diabetes and CVD.