Clinical characteristics of coronary artery disease in patients with nonalcoholic fatty liver disease
10.3760/cma.j.issn.1000-6699.2010.07.004
- VernacularTitle:冠心病患者伴非酒精性脂肪性肝病的临床特征分析
- Author:
Ye WANG
;
Zhigang LU
;
Meifang GAO
;
Mi ZHOU
;
Yuqian BAO
;
Weiping JIA
- Publication Type:Journal Article
- Keywords:
Nonalcoholic fatty liver disease;
Coronary artery disease;
Coronary angiography
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(7):541-544
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics of coronary artery disease (CAD) in patients with nonalcoholic fatty liver disease ( NAFLD). Methods Totally 234 subjects underwent coronary angiography, including 148 men and 86 women with complete data on metabolic syndrome ( MS) and abdominal ultrasonography; the mean age was 66. 6 years. The severity of CAD was assessed by coronary stenosis index (CSI). Metabolic syndrome was diagnosed according to the Guideline on Prevention and Treatment of Blood lipid Abnormality in Chinese Adults. Results Ultrasonography revealed that 62 patients had NAFLD (26. 5%). In patients with NAFLD, the prevalence of central obesity was higher than those without NAFLD (75. 8% vs 50. 0% , P< 0.01). With regards to age, CAD patients with NAFLD were more common in patients under 60 years (27.4% vs 13.7% , P=0.005). CSI score was similar in CAD subgroup and CAD & NAFLD subgroup (P>0.05), however the age of patients in CAD & NAFLD subgroup was significantly lower compared to CAD subgroup ( P = 0.006). According to the results of logistic regression, central obesity was the independent risk factor of NAFLD (β= 1.701, P<0.001). Logistic regression demonstrated that age was independently associated with CAD (β = 0.032, P=0.027). Further more, multiple stepwise regression analysis showed that age was the single parameter that best predicted CSI score (β= 0. 125, P = 0. 022). Conclusions It is important to screen coronary artery disease in middle aged patients with central obesity or NAFLD.
