Protecting function of heme oxygenase-1 in human liver transplantation
10.3760/cma.j.issn.1007-8118.2010.07.008
- VernacularTitle:血红素氧合酶-1在临床肝移植中肝脏保护作用的研究
- Author:
Huawei SU
;
Shibo SUN
;
Tiewei SUN
;
Dequan WU
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Heme oxygenase-1;
Ischemia/reperfusion injury
- From:
Chinese Journal of Hepatobiliary Surgery
2010;16(7):504-507
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relation of donor liver's heme oxygenase-1 level to ische-mia/reperfusion injury and the liver function after liver transplantation. Methods Twenty-eight pa-tients receiving orthotopic liver transplantation (OLT) were divided into two groups according to the donor liver's heme oxygenase level of high HO-1 expression group and low HO-1 expression group.The recipients' serum levels of ALT, AST, bile salt output and the expression of HO-1 mRNA were determined and compared between the 2 groups. Results HO-1 mRNA of low expression group in-creased significantly after the reperfusion. Meanwhile, the HO-1 mRNA of high expression group de-creased. The serum levels of ALT and AST of HO-1 in low expression group were much lower but bile salt concentration higher than those in high expression group. Conclusion HO-1 can be further induced in the liver of HO-1 low expression group during the reperfusion period. The I/R injury in the HO-1 low expression group was less severe than that in high expression group, but the liver function was better. The increase of HO-1 during the transplantation seems better for protecting the liver than the initial HO-1 high expression. Kupffer cells are of the main localization for HO-1 protein in human liver.
