Progress in enhancing radiosensitivity by inhibition of DNA double strand break repair
10.3760/cma.j.issn.1673-422X.2010.05.012
- VernacularTitle:以DNA双链断裂修复基因为靶点的肿瘤放射增敏研究
- Author:
Ligang XING
;
Xiaorong SUN
- Publication Type:Journal Article
- Keywords:
DNA double strand break;
Radiosensitivity;
Gene therapy
- From:
Journal of International Oncology
2010;37(5):358-361
- CountryChina
- Language:Chinese
-
Abstract:
DNA double strand breaks are potentially lethal DNA lesions induced by ionizing radiation, which can be repaired by homologous recombination and non- homologous end joining. Inhibition of the expression and function of genes in double strand breaks repair pathways using RNA interference and anti- sense techniques could improve the radiosensitivity of cancer cells.
