The clinical significance of gene polymorphism in children's primary nephrotic syndrome
10.3760/cma.j.issn.1673-4408.2010.04.019
- VernacularTitle:基因多态性在儿童原发性肾病综合征中的临床意义
- Author:
Juan CHEN
- Publication Type:Journal Article
- Keywords:
Children;
Nephrotic syndrome;
Gene;
Polymorphism(Genetics)
- From:
International Journal of Pediatrics
2010;37(4):393-395
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of children's primary nephrotic syndrome has not been completely clear at present.In the past few years,The polymorphism of these genes,such as angiotensin-converting enzyme gene,apolipoprotein E gene,platelet-activating factor acetylhydrolase gene,human histocompatibility leukocyte antigen gene,glucocorticoid receptor gene and cytokine gene,ect have been discovered that were significantly correlated with susceptibility,pathological progress,steroid response,disease recurrence and prognosis of primary nephrotic syndrome.This article reviewed the research progress of PNS and gene polymorphism.
