A new method for improvement the oxidative stage of 10 beta-allyldeoxoartemisinin into 10 beta-(2-carboxymythel) deoxoartemisinin compound
- Author:
Tran Khac Vu
- Publication Type:Journal Article
- Keywords:
Artemisinin
- MeSH:
Artemisinins;
Pharmaceutical Preparations
- From:Pharmaceutical Journal
2005;0(7):11-13
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The synthesis of 10 beta-allyldeoxoartemisinin with excellent results through the intermediate dihydroartemisinin 10 alpha-benzoate using zinc chloride as catalyst was performed. This compound was then oxidized using osmium tetra oxide and oxone in dimethyl formamide to give 10 beta-(2'-carboxymethyl) deoxoartemisinin with high yield. Many important different derivatives of artemisinin can be synthesized from this important compound
