Discussion on adverse reactions of gonadotropin releasing hormone agonists as the treatment of precocious puberty in girls
10.3760/cma.j.issn.1673-4408.2010.04.032
- VernacularTitle:促性腺激素释放激素激动剂治疗女童性早熟的不良反应探析
- Author:
Rong HUANG
- Publication Type:Journal Article
- Keywords:
Gonadotropin releasing hormone agonist;
Gonadotropin releasing hormone analogue;
Precocious puberty;
Adverse reaction
- From:
International Journal of Pediatrics
2010;37(4):432-435
- CountryChina
- Language:Chinese
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Abstract:
Gonadotropin releasing hormone agonists(GnRHa)are the relatively safe drugs widely used in clinic to treat precocious puberty.After therapy withdrawal,the patients would have normal menstrual onset,gestation and fertility.GnRHa didn't degrade uterus volume of post puberty.After cessation of GnRHa,luteinizing hormone,follicle stimulating hormone and sex hormone levels would return to those before therapy,or even exceed them.Some researches suggested that gonadotropin releasing hormone analogue might increase the risk of androgen excess and polycystic ovary syndrome.The researches apply no sufficient evidences to show that GnRHa had significant and irreversible negative influences on bone mineral density.GnRHa might have the side effect of increasing body mass index(BMI).However,researches also showed that GnRHa was helpful to decrease BMI,or not to increase it.
