The roles of occludin in changes of Wood-brain barrier permeability
10.3760/cma.j.issn.1673-4165.2010.06.014
- VernacularTitle:咬合蛋白在血脑屏障通透性改变中的作用
- Author:
Ping GUO
;
Qiquan ZHOU
- Publication Type:Journal Article
- Keywords:
Blood-brain barrier;
Tight junctions;
Membrane proteins;
Brain edema;
Hypoxia,brain
- From:
International Journal of Cerebrovascular Diseases
2010;18(6):466-472
- CountryChina
- Language:Chinese
-
Abstract:
As an important transmembrane protein in brain microvascular endothelial cells tight junction, occludin plays important roles in regulating and maintaining blood-brain barrier permeability. Its abnormal expression can increase blood-brain barrier permeability. In order to provide some theoretical supports for the roles of studying occludin intensively in the mechanisms of blood-brain barrier permeability-related diseases and targets for pharmacological intervention, this article reviews the roles of occludin in the molecular composition and functional maintenance of blood-brain barrier tight junction, as well as the changes of cerebral microvascular permeability during hypoxia.
