Animal models and evaluation methods of ischemic brain injury
10.3760/cma.j.issn.1673.4165.2010.06.015
- VernacularTitle:缺血性脑损伤的动物模型及其评价方法
- Author:
Yifeng MIAO
;
Xiaojie LU
;
Yongming QIU
- Publication Type:Journal Article
- Keywords:
Brain ischemia;
Brain injury;
Disease models,animal
- From:
International Journal of Cerebrovascular Diseases
2010;18(6):473-476
- CountryChina
- Language:Chinese
-
Abstract:
The experimental study of cerebral ischemia plays an important role for understanding the pathogenesis of ischemic brain injury, but its correlation with the clinical therapeutic strategies has certain limitations. One of its main reasons is that the experimental models and methods can not or only partially repeat the pathophysiological processes of natural cerebral ischemia. In order to promote the understanding and interpretation of the experimental data, we review the commonly used experimental animal models and modeling methods and mainly elaborate the methods of current different in vivo and in vitro clinical evaluation. Based on these studies, we believe that the standardized clinical evaluations are hugely important for assessing the experimental results and clinical transformation.
