Thrombospondin-1 and taxol resistance
10.3760/cma.j.issn.1673-422X.2010.05.007
- VernacularTitle:血小板反应蛋白1与紫杉醇耐药机制的研究
- Author:
Xiaofeng YAO
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Taxoids;
Tubulin
- From:
Journal of International Oncology
2010;37(5):341-344
- CountryChina
- Language:Chinese
-
Abstract:
Thrombospondin-1 is known as its anti-angjogenic and proapoptotic activities in oncogenesis. In current research, it has a intimate relationship with taxol resistance. Sensitivity of tumor cells to taxol will descend when the expression:of TSP1 is downregulated,and TSP1 downregulation is mediated by a new gene of taxol-resistance gene 1, the discovery provids a new trend to solve taxol resistance.
