Advance in the ACTH therapeutic mechanisms of infantile spasms
10.3760/cma.j.issn.1673-4408.2010.04.025
- VernacularTitle:促肾上腺皮质激素治疗婴儿痉挛症作用机制研究进展
- Author:
Zhanli LIU
- Publication Type:Journal Article
- Keywords:
Spasms,infantile;
Adrenocorticotropic hormone;
Epilepsy
- From:
International Journal of Pediatrics
2010;37(4):413-415
- CountryChina
- Language:Chinese
-
Abstract:
Infantile spasms is a severe and refractory epileptic encephalopathy that occurs in infancy and early childhood.Adrenocorticotropic hormone (ACTH) has been the major therapy for infantile spasms.However,the ACTH therapeutic mechanisms of infantile spasms still lack relatively reasonal explaination.Recent researches has been found that ACTH might produce its herapeutic effect by suppression of excessive secretion and releasing of corticotrophin releasing hormone,modulation of production and releasing of neurosteroids,neurotrophins,and other putative pathways.
