Expression of osteopontin in epithelial ovarian cancer tissue and its relation to the prognosis
10.3760/cma.j.issn.1008-6315.2010.08.002
- VernacularTitle:骨桥蛋白在卵巢上皮癌组织中的表达及其与预后的关系
- Author:
Xiaoyu DONG
;
Jinghua YANG
;
Cuifen SUN
;
Yuxia DONG
;
Yujie YAO
;
Han WEI
- Publication Type:Journal Article
- Keywords:
Osteopontin;
Epithelial ovarian cancer;
Immunohistochemisty;
Prognosis
- From:
Clinical Medicine of China
2010;26(8):788-790
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of osteopontin ( OPN) in epithelial ovarian cancer tissue and its prognostic value. Methods The immunohistochemistry method was used to detect the expression of OPN in 64 cases of epithelial ovarian cancer tissue, and 20 cases with ovarian benign tumors and 10 normal ovarian tissues as well. The relationship between the OPN expression and clinical pathological characteristics and its prognostic value were analyzed statistically. Results The positive expression of OPN case was confirmed in 52 cases in 64 epithelial ovarian cancer. The expression level of OPN in epithelial ovarian cancer tissue was significantly higher than that in benign ovarian tumor and normal control (P <0. 01). The OPN expression in epithelial ovarian cancer tissues was associated with the pathological grading, lymphatic metastasis and production of ascites. The survival time is longer in OPN negative patients than the positive group. Conclusions OPN plays an important role in the tumorgenesis and development of epithelial ovarian cancer and correlates with its prognosis.
