Analysis of circulating Th17 cells and regulatory T cells in mynsthenia gravis
10.3760/cma.j.issn.1006-7876.2010.08.014
- VernacularTitle:重症肌无力患者外周血Th17和调节性T细胞分析
- Author:
Qihua CHEN
;
Xiang ZHANG
;
Xiang LI
;
Jian QIAO
;
Jiahong LU
- Publication Type:Journal Article
- Keywords:
Myasthenia gravis;
T-lymphocytes,helper-inducer;
T-lymphocytes,regulatory;
Methylprednisolone
- From:
Chinese Journal of Neurology
2010;43(8):568-571
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the percentage of Th17 cells and regulatory T cells in patients with myasthenia gravis (MG) and observe the effects of methylprednisolone infusion on these cells.Methods The circulating Th17 cells and CD4+ CD25highT cells of 66 MG patients and 35 healthy controls were detected using four colour cytometry. The relationship between these cells and MGFA score in 18 MG patients and in 8 MG patients after methylprednisolone was infusion were also analyzed in this study. Results There was significant difference in the percentage of circulating Th17 cells between MG patients (2. 61% ±0. 28% ) and the healthy controls (0. 94% ± 0. 12%, Z = 4. 059, P = 0. 0001 ). Methylprednisolone therapy significantly reduced the percentage of circulating Th17 cells from 4. 72% ± 1.21% to 1.81% ± 0. 69%(Z = 1. 995,P = 0. 0460). In addition, the percentage of Th17 cells showed a positive correlation with MGFA score(r =0. 5359, P =0. 0219). Conclusions Circulating Th17 cells are elevated in MG patients.Methylprednisolone therapy can reduce such elevation, and this may be important in mediating symptomatic improvement in MG patients.
