An analysis of opportunistic infection in 762 inpatients with human immunodeficiency virus infection in Guangdong areas
10.3760/cma.j.issn.0578-1426.2010.08.006
- VernacularTitle:广东地区762例住院人类免疫缺陷病毒感染患者机会性感染分析
- Author:
Lifen HUANG
;
Xiaoping TANG
;
Weiping CAI
;
Xiejie CHEN
;
Chunliang LEI
;
Linghua LI
;
Fuchun ZHANG
- Publication Type:Journal Article
- Keywords:
Acquired immunodeficiency syndrome;
Opportunistic infections;
CD4 lymphocyte count
- From:
Chinese Journal of Internal Medicine
2010;49(8):653-656
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristics of opportunistic infection (OI) in patients with HIV/AIDS in Guangdong and the relationship between OI and the change in blood CD4+ T lymphocyte count (CD4+ ).Methods Seven hundred and sixty two patients with HIV/AIDS admitted were analyzed. Results Among all the 762 patients, 704 (92.39% ) had more than one kind of OI, with 1428 episodes totally.Etiologically, fungus infection (38.38% ) was most common, followed by bacteria (36.20% ), and virus (7.77% ) infection. Most OI occurred in the lungs (33.05% ), mouth (26.89% ), skin (10.29% ) and gastro-intestine (8.96% ).Septicemia and other systemic disseminated diseases accounted for 6.58% and 9.94% respectively.The incidence of OI in patients with CD4+= 200/μ1 (103/136, 75.74%) was significantly lower than that in patients with CD4+ <200/μ1 (601/626, 96.01%), P<0.01.All the AIDS defining OI were found in patients with CD4+ <200/μ1 Among them, 81.97% of patients with pneumonia carinii pneumonia (PCP), 71.43% of patients with cytomegalovirus retinitis and all the patients with cryptococcal meningitis, disseminated cryptococosis, disseminated histoplasmosis, mycobacterium avium intracellular complex (MAC), disseminated penicilliosis mameffei and toxoplasma cerebritis had the CD4+ less than 50/ μ1.Conclusions The most common OI in patients with AIDS in Guangdong area are fungi, bacterial and viral infections.Lung, mouth, skin, gastro-intestine and systemic disseminated infections are the most prevalent infections.As the CD4+ decreased, the incidence of OI especially AIDS defining OI increased. Dynamic detection of CD4+ will be of great help for the prediction, prevention, early diagnosis and treatment of OI in patients with AIDS.
