Effect of cirrhosic liver on dynamic vascular curves analysis of hepatocellular carcinomas at contrast-enhanced ultrasound
10.3760/cma.j.issn.1004-4477.2010.07.010
- VernacularTitle:肝硬化背景对肝细胞癌超声造影灌注曲线的影响
- Author:
Xiaoqing PEI
;
Longzhong LIU
;
Min LIU
;
Yuhong LI
;
Anhua LI
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Carcinoma,hepatocellular;
Hemodynamic phenomena
- From:
Chinese Journal of Ultrasonography
2010;19(7):576-579
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of cirrhosic liver on dynamic vascular curves analysis f(t)of hepatocellular carcinomas(HCCs) at contrast-enhanced ultrasound by exploring the difference between perfusion parameters of HCCs in cirrhotic liver and that in noncirrhotic liver. Methods One hundred and fifteen HCCs were analyzed off-line with dynamic vascular curve f(t) of Sonoliver. The HCCs were divided into 2 groups based on their background liver as cirrhotic liver group ( n = 86) and noncirrhotic liver group ( n =29). Such parameters as maximum of intensity(IMAX) ,rise time (RT,from 10% to 90% of IMAX),time to peak(TTP) ,mean trasit time(mTT) ,rise slope(RS) and washout time(WT) of the two groups were analyzed by statistics. Results There was no significant difference in the f(t) parameters of HCCs between cirrhotic liver group and noncirrhotic group(P >0. 05) [IMAX:(124. 25 ± 5. 56)% vs (113. 65 ± 5. 58)% ; RT: (12. 98 ± 0. 48)s vs (13. 68 ± 0. 92)s;TTP:(13. 70 ± 0. 52)s vs (14. 39 ± 0. 9)s;mTTi(138. 61 ± 9. 20)s vs (149. 49 ± 21. 70)s;RS:10. 11 ± 0. 60 vs 8. 89 ± 0. 77, WT: (34.17 ± 2. 91 )s vs (28. 36 ± 3. 25)s]. There was also no significant statistical difference in all above parameters in reference regions for the two group (P > 0. 05). Conclusions The f(t) parameters in HCCs can evaluate blood perfusion of the tumors, and cirrhotic liver does not affect the perfusion parameters of HCCs.
