Study on the correlation of duration of reproductive period and prognosis of acute ischemic stroke

VernacularTitle:生育期时间与女性缺血性脑卒中预后的关系
Author: Bo SONG ; Rui ZHANG ; Song TAN ; Yuan GAO ; Lu ZHAO ; Jiameng LU ; Guang YANG ; Yuming XU
Publication Type:Journal Article
Keywords: Brain ischemic stroke; Stroke; Female; Menarche; Menopause; Prognosis
From: Chinese Journal of Neurology 2010;43(8):551-554
CountryChina
Language:Chinese
Abstract: Objective To study a possible correlation between the duration of reproductive period ( from puberty to menopause) and the prognosis of ischemic stroke. Methods Female in-patients with acute ischemic stroke confirmed by CT/MRI in the Neurology Department of the First Affiliated Hospital of Zhengzhou University from 09/03/2006 to 08/30/2008 were enrolled in this study. The probable risk factors of prognosis were analyzed and recovery was assessed by modified Rankin score (MRS) at 6 months followup. Multivariate Logistic regression was used for statistic analysis. Results 371 female patients were enrolled. The average age was (66. 2 ± 10. 0) years; average menopause age was (48. 5 ± 3.9 ) years and average duration of reproductive period was (33.3 ± 4. 3) years. There is a negative correlation between the duration and MRS (OR =0. 285, 95% CI: 0. 095-0. 850, P =0.024). There is no correlation between menopause age and prognosis of stroke. Conclusions Duration of reproductive period is a predictor for prognosis of ischemic stroke. Patients with longer reproductive period have better prognosis.