The clinico-pathological manifestation of cardiac involvement in eosinophilic diseases
10.3760/cma.j.issn.0578-1426.2010.08.013
- VernacularTitle:嗜酸性粒细胞增多症患者心脏受累的临床和病理表现
- Author:
Zhuang TIAN
;
Quan FANG
;
Dachun ZHAO
;
Quancai CUI
;
Yongtai LIU
;
Yong ZENG
;
Mengtao LI
;
Xiuchun JIANG
- Publication Type:Journal Article
- Keywords:
Pulmonary eosinophilis;
Heart;
Pathology
- From:
Chinese Journal of Internal Medicine
2010;49(8):684-687
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical and pathological features of eosinophilic diseases with cardiac involvement Methods We analyzed the clinical and cardiac pathological data of 7 patients with eosinophilic diseases with cardiac involvement under endomyocardial biopsy or autopsy.Results Seven patients (5 male, average age 51 years) were enrolled.Four patients were diagnosed as idiopathic hypereosinophilic syndrome and three were Churg-Strauss syndrome.Peripheral blood eosinophila count increased significantly in all patients.Cardiac involvement included angina pectoris, myocardial infarction, heart failure, presyncope and sudden death.Electrocardiogram showed cardiac ischemia, bundle branch block and third degree atrioventricular block.Echocardiography suggested ventricular and atrial enlargement, decreased ventricular systolic function, pulmonary hypertension, valvular prolapse and insufficiency and endocarditis.Pathology displayed infiltration of eosinophils, formation of granulomata, necrotizing vasculitis, myocardial necrosis and endomyocardial fibrosis in heart.Coronary artery could be also affected and led to myocardial infarction.Conclusions Cardiovascular complications of eocinophilic diseases are a major source of morbidity and mortality in these disorders.The manifestations are multiple and early recognition and treatment with steroid and immunosuppressant can improve prognosis.
