Association of TGFβ1-509 C/T gene polymorphism and ANCA associated vasculitis in Chinese Han population
10.3760/cma.j.issn.1008-6315.2010.08.006
- VernacularTitle:转化生长因子-β1基因-509 C/T多态性与原发ANCA相关性小血管炎的关联研究
- Author:
Chao XUE
;
Zuojie LUO
;
Yunhua LIAO
;
Xin XIANG
;
Jia XU
;
Mingjun WANG
;
Wei FENG
- Publication Type:Journal Article
- Keywords:
ANCA;
Transforming growth factor-beta 1;
Gene Polymorphism;
Association
- From:
Clinical Medicine of China
2010;26(8):798-801
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between TGFβ1-509 C/T gene polymorphism with primary ANCA associated vasculitis (AAV) in Chinese Han population . Methods The blood DNA and clinical data of 88 patients were collected, TGFβ1-509 C/T genotypes were determined by PCR-RFLP, 107 healthy individuals were tested as controL Clinical and pathological data of the patients with different genotype were compared. Results No significant difference was found in neither genotype distributions nor allele frequencies between the patients and the control (P > 0. 05). Significant difference was found in uria protien level of the three groups of patients with different genotypes(P <0.05) ,but not in blood pressure, serum urea nitrogen or creatinine, vasculitic damage index, birminghan vasculitis activity score (P > 0. 05 ). Significant difference was found in med-heavier glomerular mesangial proliferation of the three groups ( P < 0.05 ) , but not in lighter glomerular mesangial proliferation, glomerular sclerosis, crescent formation and tubule-interstitial fibrosis and atrophy. Conclusions In Chinese Han population, TGFβ1-509 C/T polymorphism might have no relationship to susceptibility of primary AAV, but might relate to uria protein and med-heavier degree of mesenterium proliferation.
