Indoleamine 2,3-dioxygenase and immune tolerance in the gallbladder carcinoma
10.3760/cma.j.issn.1673-4203.2010.07.016
- VernacularTitle:IDO与胆囊癌的免疫耐受
- Author:
Peng ZHANG
;
Xingyuan JIAO
;
Jingsen SHI
- Publication Type:Journal Article
- Keywords:
Indoleamine 2,3-dioxygenase;
Immune tolerance;
Dendritic cell;
Gallbladder neoplasms;
Tryptophan
- From:
International Journal of Surgery
2010;37(7):476-479
- CountryChina
- Language:Chinese
-
Abstract:
Indoleamine 2,3-dioxygenase(IDO)is the rate-limiting enzyme in the catabolism of trypto-phan along the kynurenine pathway.Over expression of IDO is one of the reasons which are responsible for immune tolerance of tumor.IDO also affects the effects of the vaccine of the dendritic cell in the tumor therapy.Lipopolysaccharide(LPS),cytokines and so on can regulate the expression of IDO via different regulating mechanisms.IDO participates in the local immune tolerance of tumor by three kinds of mechanisms.Further research on this immunological regulatory mechanism will be significant for tumor immunotherapy.
