Association of thromboxane A2 receptor gene polymorphism with wheezing episode after RSV infection in children
10.3760/cma.j.issn.1008-6315.2010.08.005
- VernacularTitle:血栓素A2受体基因多态性与儿童呼吸道合胞病毒感染后喘息发生的相关性研究
- Author:
Xueyan WANG
;
Changshan LIU
;
Zhong HAN
- Publication Type:Journal Article
- Keywords:
Asthma;
Children;
Thromboxane A2 receptor;
Gene polymorphism;
Respiratory syncytial virus
- From:
Clinical Medicine of China
2010;26(8):795-797
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential role of respiratory syncytial virus (RSV) in wheezing episode in children, and to assess the association of the thromboxane A2 receptor gene (TBXA2R) T924C polymorphism with wheezing after RSV infection. Methods From may to december in 2008, one hundred and twenty-five asthmatic children who were suffering from acute episode were recruited as cases and 49 healthy children as controls in our Polymerase chain reactions-Restriction fragment length polymorphism (PCR-RELP) techniques were used to detect the TBXA2R SNP. RSV IgM and IgG were measured by ELISA. Results RSV specific antibody was positive in 57 asthmatic patients (45.6% ,57/125) and 8 controls (16.33% ,8/49) ,with significant difference between the two groups ( χ2 = 12. 890, P = 0. age asthmatic group and 76. 92% (30/39) in the <3 years of age asthmatic group, with significant difference between the two groups (χ2 = 22. 420, P = 0. 000 ). The genotypes distribution in the asthmatic patients was significantly different from that in the controls(χ2 = 5. 346, P = 0. 021). The frequency of TC and CC genotypes in the cases was significantly higher than that in the control group. The allele frequencies of T and C allele were similar in the two groups ( χ2 =2.660, P=0.103). Conclusions RSV infection was one of the factors that associated with asthma acute episode, especially in children younger than 3 years. The TC,CC genotypes increase the chance of wheezing in children infected by RSV.
