Diagnosis value of serum CYFRA21-1 level in lung cancer
10.3760/cma.j.issn.1008-6315.2010.08.016
- VernacularTitle:细胞角蛋白19片段检测对肺癌的诊断价值
- Author:
Yonghua HU
;
Lei YANG
;
Feng DONG
;
Jiguo NIU
;
Shu MEI
;
Ruiping ZHAO
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Serum CYFRA21-1;
Diagnosis
- From:
Clinical Medicine of China
2010;26(8):825-827
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical application of serum CYFRA21-1 detection during the diagnosis of lung cancer. Methods Serum level of CYFRA21-1 in 196 patients with lung cancer and 39 healthy controls were determined by the Elctro-chemiluminescence Immuno-assay ( ECLIA) , respectively. Results Serum level of CYFRA21 -1 ( range from 0. 30 μgg/L to 500.00 μg/L) in patients with lung cancer were significantly higher than those in the healthy control ( range from 0. 27 μg/L to 3. 29 μg/L,Z = -4. 65,P < 0.01). ROC analysis of diagnosis efficiency showed that the area under curve ( AUC) was 0. 735 (P < 0. 001 ). The confidence interval of 95% was from 0. 663 to 0. 807. Positive detection rate of CYFRA21-1 was 48. 8% (39/80) in squamous,31.7% (20/63) in adenocarcinoma and 22. 6% (12/53) in small cell lung cancer (SCLC) respectively, as well as total positive rate was 36. 2% (71/196). Stepwise regression analysis showed that serum level of CYFRA21-1 had a linear correlation with the squamous and the metastasis to liver or bone (r =0. 505 ,P <0. 05). Conclusions Serum level of CYFRA21-1 increases the diagnostic sensitivity, which is helpful for determining histological types, monitoring the metastasis of liver and bone, and evaluating the treatment response in patients with lung cancer.
