Clinical analysis of 18 cases of drug hypersensitivity syndrome

VernacularTitle:药物超敏综合征18例临床特征分析
Author: Xianting XV ; Jie XU ; Xiaomin LIN ; Yongzhen JIN
Publication Type:Journal Article
Keywords: Drug hypersensitivity; Side effects
From: Chinese Journal of Postgraduates of Medicine 2010;33(21):11-13
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical features of drug hypersensitivity syndrome(DHS). Method Retrospective analysis of 18 cases of DHS was made in detail including clinical situation, laboratory examination, treatment instance,duration and prognosis. Results The earliest symptoms of all patients were skin rash and fever, which occurred in 2 to 8 weeks after the administration of the drugs, accompanied with superficial lymphadenopathy in 13 patients, liver dysfunction in 14 patients, renal impairment in 11 patients, leukocytosis in 13 patients and eosinophilia in 10 patients. The skin lesions were multiform. The common eruption was purpura-like erythemas, accompanied with swelling and repeated desquamation. The suspected drugs were as follows: allopurinol in 11 cases, carbamazepine in 4 cases, phenytoin in 2 cases and minocycline in 1 case. Corticosteroid was the first line of treatment Conclusions DHS is a clinical syndrome to have characteristic symptom and a relatively severe disease. It is crucial to discontinue the suspected drugs promptly and to start sufficient dose of corticosteroid.