Gray matter volume differences in deficit and nondeficit schizophrenia:a voxel-based morphometric study
10.3760/cma.j.issn.1674-6554.2010.07.004
- VernacularTitle:运用基于体素的脑形态测量学法检测缺陷型及非缺陷型精神分裂症患者脑灰质结构异常
- Author:
Xiaosheng WANG
;
Xiang WANG
;
Lirong YAN
;
Changlian TAN
;
Weijun SITU
;
Yajun LI
;
Shuqiao YAO
- Publication Type:Journal Article
- Keywords:
Deficit schizophrenia;
Magnetic resonance imaging;
Voxel-based morphometry;
Cray matter
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(7):587-590
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the differences in the structure of brain white matter among deficit schizophrenia, nondeficit schizophrenia and healthy controls by using voxel-based morphometry (VBM). Methods Ten deficit schizophrenic patients, eleven nondeficit patients and fifteen healthy comparison subjects participated in the study. All the subjects were scanned by GE Twin Speed 1.5T MRI system. Whole brain, voxel-wise analyses of regional white matter volume were conducted by the VBM toolbox on the Matlab7.6 and SPM5. t -test was then used for the comparison between groups. Results Compared to the healthy controls, nondeficit schizophrenic patients significantly decreased the density of gray matter in the frontal, parietal, temporal, occipital lobe and basal ganglia , while the deficit patients showed the characteristically broad and significant decreasion in the frontal lobe, including left medial frontal gyrus, bilateral inferior frontal gyrus, left middle frontal gyrus, and left orbital gyrus (Cluster ≥ 30 mm3, P<0.01). Moreover, deficit patients showed the decreasion in the temporal cortex and the limbic lobe (right insula). Relative to the nondeficit schizophrenic patients, deficit patients had significant regional gray matter decreases in the left medial frontal gyrus, bilateral inferior frontal gyrus, right precentral gyrus, and right superior temporal gyrus (Cluster ≥ 30 mm3, P<0.01). Conclusion Structural heterogeneity in schizophrenia may relate to specific patterns of gray matter density reductions in deficit and nondeficit patient. However the two subtype of schizophremia patients share a common prefrontal-temperal pattern of structural brain alterations.
