Study on the Correlation between the Polymorphism of Interferon -γGene and Susceptibility to the Development of Lung Cancer
10.3760/cma.j.issn.1008-6706.2010.15.027
- VernacularTitle:γ-干扰素基因多态性与肺癌易感性的关系研究
- Author:
Weihua ZHANG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Interferon-γ gene;
Polymorphism;
Susceptibility
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(15):2071-2073
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between the polymorphism of Interferon γ( IFN-γ) ( + 874 T/A) gene and susceptibility to the development of lung cancer. Methods The polymorphism of IFN-7 gene( + 874 T/A) in 42 patients with lung cancer and 60 healthy control subjects was detected by using sequence-specific primers polymerase chain reaction( PCR-SSP) and their susceptibility to development of lung cancer was analyzed. Results The genotypic frequencies of AA of IFN -γ Gene( + 874 T/A) in the control group and the patient group were 0. 533, 0.786 .respectively and the genotypic frequency of AA in control group was significantly lower than that in the patient group ( P < 0. 01) , in contrast with which the genotypic frequencies of AT and TT in the control group were significantly higher than those in the patient group (P < 0. 01 ,P < 0.05). The A allele frequency of IFN-γ gene in the patient group was statistically higher compared with that in the control group(0. 869 vs. 0.7 ,P <0.01 ) ,in which the relative riskrate(RR) was 2.84,95%CI 1. 31 ~6.15 ,P<0. 01. Conclusion The polymorphism of IFN-γ gene ( +874 T/ A) could be associated with susceptibility to the development of lung cancer,so it could be considered one of the genetic markers to be used to early identify individuals at high risk of lung cancer.
