Clinical significance of plasma nitric oxide, nitric oxide synthase and matrix metalloproteinase 9 in patients with cervical cancer
10.3760/cma.j.issn.1008-6706.2010.13.012
- VernacularTitle:血浆一氧化氮、一氧化氮合酶和基质金属蛋白酶9在子宫颈癌中的临床意义
- Author:
Senge DAI
- Publication Type:Journal Article
- Keywords:
Uterine neoplasms;
Nitric oxide;
Nitric oxide synthase;
Matrix metalloproteinase 9
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(13):1753-1754
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of plasma NO,NOS and MMP-9 variences in patients with cervical cancer. Methods 69 cervical cancer patients were studied. Patients with cervical cancer, 1 day before surgery,after 15 days,30 days of fasting peripheral,and healthy control group with fasting blood,venous blood drawn respectively. Plasma NO, NOS and MMP-9 levels were detected by chemical assay and ELISA assay. Comparing the changes in these indicators and their correlation. Results Compared with healthy control group,plasma NO, NOS,MMP-9 levels were significant higher in cervical cancer patients. Compared to before surgery,the plasma NO, NOS,MMP-9 were significantly lower in surgery after 15 days,30 days,but still significantly higher than normal. Patients with cervical cancer with lymph node metastasis NO, NOS, MMP-9 levels were significantly higher than those without lymph node metastasis,correlation analysis showed that serum MMP-9 and NO,NOS had significant positive correlation. Conclusion Detection of plasma NO, NOS and MMP-9 levels, it was better to evaluate the condition of cervical cancer and serve guidelines of clinical treatment.
