Clinical observation of 10-days sequential treatment to eradicate helicobacter pylori

VernacularTitle:10日序贯疗法根除幽门螺杆菌的临床观察
Author: Yukai HUANG ; Jin ZHOU ; Bin XU
Publication Type:Journal Article
Keywords: Helicobacter Pylori; Ofloxacin; Rabeprazole
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(13):1760-1761
CountryChina
Language:Chinese
Abstract: Objective To compare the efficacy of 10-days sequential treatment( including rabeprazole,amoxillin, levofloxacin and tinidazole) and traditional trigeminy therapy (including rabeprazole, amoxillin and clarithromy-cin) for the eradication of helicobacter pylori ( Hp). Methods 90 patients with Hp positive who were detected by 14C urea breath test or gastroscope Hp test were randomly divided into two groups: the therapeutic group and the control group. The therapeutic group was treated with rabeprazole,amoxillin at first 5 days,rabeprazole,levofloxacin and tinidazole at the second 5 days,while the control group was treated with rabeprazole,amoxillin and clarithromycin for 10 days. The 14C urea breath test was detected after course of treatment finished in a month. Results The eradication rate of 10 days sequential treatment was 93. 3% and that of control group was 75. 6% ,and the difference between two groups was significant(P <0.05). Conclusion Comparing with traditional trigeminy therapy,the 10-days sequential treatment comprising rabeprazole and levofloxacin could achieve a higher eradication rate of Hp.