Clinical observation of arthroscopic debridement with injecting chuanxiongqin in treating knee osteoarthritis
10.3760/cma.j.issn.1673-4904.2010.21.009
- VernacularTitle:关节镜下关节清理术并腔内注射川芎嗪对膝关节骨性关节炎的临床观察
- Author:
Fangtao DU
;
Jie ZHANG
;
Bo SHANG
;
Xiaoran YANG
;
Qian ZHANG
- Publication Type:Journal Article
- Keywords:
Arthroscopy;
Osteoarthritis,knee;
Nitric oxide;
Chuanxiongqin
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(21):21-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical therapeutic effect of arthroscopic debridement cooperated with injecting chuanxiongqin in treating knee osteoarthritis. Methods Sixty cases of knee osteoarthritis were randomly divided into 2 groups: treating group and control group, 30 cases in each group. The treating group were treated by arthroscopic debridement cooperated with injecting chuanxiongqin;the control group were given hyaluronate-Na after received arthroscopic debridement. The operation evaluation criteria of JOA was taken to value the therapeutic effect at 1 week, 3 months, 6 months and 12 months postoperation. At the same time, nitric oxide (NO) content in joint fluid were measured at preoperation, 1 week, 4 weeks, 3 months postoperation. Results At 1 week postoperation, there were no statistically significant differenced > 0.05) between the two groups,at 3, 6 and 12 months postoperation, the therapeutic effect of the treating group were much better than those of the control group (P < 0.01);NO content in joint fluid of preoperative treatment group [(90.32 ± 22.24) μmol/L]and control group [(90.31 ±22.20) μ mol/L]was similar, there was no significant difference (P >0.05). At 3 months postoperation, NO content in joint fluid of the treating group [(85.63 ± 30.63) μ mol/L]decreased significantly compared with preoperative (P < 0.05 ) , and the content was much lower than that of the control group [(89.66 ± 20.63 ) μ mol/L], there was significant difference between the two groups (P < 0.05). Although NO content in joint fluid of the control group was decreased, but the difference was not statistically significant (P >0.05). Conclusions Arthroscopic debridement with injecting chuanxiongqin in treating knee osteoarthritis can control inflammatory reaction of cartilage and synovia]in effect, improve the therapeutic effect. Therefore, it should be avalid method in treating knee osteoarthritis.
