Brief synthetic method of (N-bis(2-acyloxyethyl)-amino)-acetic acid. Application in synthesis of camptothecin-clorambucil complex utilized in the treatment of cancer
- Author:
Nguyen Hai Nam
- Publication Type:Journal Article
- Keywords:
Cancer
- MeSH:
Neoplasms;
Therapeutics;
Acetic Acid
- From:Pharmaceutical Journal
2005;0(7):7-10
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Study on synthesis of [bis(2-acyloxyethyl)-amino]-acetic acid derivatives vat by synthetic method at solid phase and applying this method to synthesize a compound between camptothecin and clorambucil. Result: camptothecin - clorambucil CPT-2CLR compound were synthesized successfully by camptothecin esterification reaction with 2 (acid[bis(2-acyloxyethyl)-amino]-acetic). The [bis(2-acyloxyethyl)-amino]-acetic acid was synthesized simply and conveniently only by three-step on solid phase from bromoacetic trityl resin, diethanolamin and clorambucil. Attained productivity started from resin was 88%. This method may be applied in the synthesis of similar prodrugs and/or twin drugs
