Clinical study of relativity between serum procalcitonin level and renal impairment in critically ill patients
10.3760/cma.j.issn.1673-4904.2010.21.001
- VernacularTitle:危重症患者降钙素原和肾损害相关性的临床研究
- Author:
Jian WU
;
Peng LI
- Publication Type:Journal Article
- Keywords:
Renal insufficiency,acute;
Acute physiology and chronic health evaluation;
Renal impairment;
Procalcitonin
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(21):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the relativity between serum procalcitonin(PCT) level and renal impairment (RI) in critically ill patients. Methods A perspective study was performed in 60 critically ill patients. They were divided into 2 groups on the serum PCT level within 24 h: abnormal group (PCT ≥ 0.5 μg/L,38 cases) and normal group(PCT < 0.5 μg/L,22 cases). The serum creatinine (SCr) and blood urea nitrogen (BUN) were observed. Acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ ) of the patients were recorded. Calculated the sensitivity and specificity for prediction of RI as well as acute renal dysfunction (ARD). Results SCr [(188.91 ± 199.48) μmol/L]and BUN [(13.03 ±9.19)mmol/L]in abnormal group were significantly higher than those in normal group [(67.40 ± 15.35) μ mol/L and (6.91 ± 2.06) mmol/L](P< 0.01). The sensitivity of PCT forecast RI was 71.79%, and specificity was 52.38%. The sensitivity of PCT forecast ARD was 91.67% , and negative predictive value was 95.45%. Conclusion Serum PCT level has an important value for judgement of RI and ARD in critically ill patients.