Experimental study on changes of CGRP-immunoreactive positive nerve fibers innervation in bone tissue of ratsand its significance

VernacularTitle:早期SANFH大鼠骨组织中CGRP免疫阳性神经纤维的变化及意义
Author: Zhenghao LU ; Ruisen ZHAN ; Shuangxi SUN ; Xiongwu LONG ; Chi YANG ; Shijie CHEN
Publication Type:Journal Article
Keywords: Femur head necrosis/ME/IM/CI; Calcitonin gene-related peptide/ME/IM; Nerve fibers/ME/IM; Hormones/AE
From: Journal of Chinese Physician 2010;12(7):872-875
CountryChina
Language:Chinese
Abstract: Objective To observe the changes of calcitonin gene-related peptide(CGRP) -immunoreactive positive nerve fibers innervation in bone tissue of femoral heads during the pathological process of early steroid-induced avascular necrosis of the femoral head (SANFH), and explore its significance.Methpathological group of SANFH was induced.Immunohistochemical technique was used and the changes of CGRP-immunoreactive positive nerve fibers innervation in weight bearing area of the femoral heads during the pathological process of early SANFH were observed.Result The number of CGRP-immunoreactive nerves increased first and then decreased ( Peaked at 6 weeks, 10.28 ± 0.66 ), but it was more than that ofnormal control group.There was significant difference between two groups ( P ＜ 0.01 ).Conclusion There were changes in the distribution of CGRP-immunoreactive positive nerves fiber during the process of bone repair after SANFH.CGRP-immunoreactive positive nerves fiber might take part in the process of bone repair in SANFH.