Comparison of Clinical Efficacy of Carvedilol and Bisoprolol in treatment Patients with Chronic Heart Failure

VernacularTitle:卡维地洛与比索洛尔治疗慢性心力衰竭疗效比较
Author: Zhouyan WANG ; Yueying ZHOU
Publication Type:Journal Article
Keywords: Heart Failure; Heart function; Carvedilol; Bisoprolol
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(15):2041-2043
CountryChina
Language:Chinese
Abstract: Objective To compare the effects of Carvedilol.Bisoprolol therapies for patients with chronic heart failure(CHF). Methods 80 patients with CHF were divided into carvedilol group(40 cases) ,Bisoprolol group (40 cases) ;The two groups were treated respectively with Carvedilol or Bisoprolol in addition to the above conventional therapy. The indicators of heart rate( HR),blood pressure( BP) ,left ventricular end-diastolic diameter( LVEDD) , left ventricular end-systolic diameter( LVESD) ,left ventricular ejection fraction(LVEF) ,6min walking test distance (6min walk) were observed after treatment and before treatment. Results Total effective rates were 82.5% and 87.5% in Carvedilol group and the Bisoprolol group,There was no statistically significant difference between two groups(χ2 =2. 18,P>0.05) ;The indicators of HR,SBP,DBP,LVEDD,LVESD after treatment were lower than before treatment ( all P < 0.05); LVEF, and 6min walk were higher than before treatment (all P < 0.05). Conclusion Bisoprolol and Carvedilol could significantly improve cardiac function in patients with heart failure.