Clinical Characteristics of Focal Segmental Glomerulosclerosis Recurrence after Adult Renal Transplantation.
10.4285/jkstn.2010.24.2.87
- Author:
Dong Jin JOO
1
;
Jung Jun LEE
;
Byung Mo LEE
;
Myoung Soo KIM
;
Kyu Ha HUH
;
Soo Jin KIM
;
Soon Il KIM
;
Yu Seun KIM
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. ysms91@yuhs.ac
- Publication Type:Original Article
- Keywords:
Focal segmental glomerulosclerosis;
Kidney transplantation;
Risk factors;
Recurrence
- MeSH:
Adult;
Glomerulosclerosis, Focal Segmental;
Graft Survival;
Humans;
Incidence;
Kidney;
Kidney Transplantation;
Recurrence;
Retrospective Studies;
Risk Factors;
Transplants
- From:The Journal of the Korean Society for Transplantation
2010;24(2):87-92
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Recurrence of focal segmental glomerulosclerosis (FSGS) after kidney transplantation is a frequent and still unpredictable complication. Moreover, risk factors for recurrence have not yet been clearly identified. METHODS: We enrolled into our study 2,882 adult kidney recipients who underwent transplantation between April 1979 and April 2009. We retrospectively reviewed clinical manifestations of recurrence of FSGS. RESULTS: Among the 2,784 adult renal recipients, forty four had undergone renal transplantation for primary FSGS. Of the 44, 12 (27.3%) showed recurrent FSGS. Mean duration between transplantation and FSGS recurrence was 22.8+/-37.4 months. There were no significant differences in patient characteristics in the recurrence and non-recurrence groups. The cumulative incidence of FSGS recurrence was 13.8% within 1 year after kidney transplantation and 23.2% within 3 years. The overall graft survival rate in the recurrence group was significantly lower than that of the non-recurrence group (P=0.0018) and non-FSGS group (P=0.0001). Graft failure happened more in the recurrence group (75%) than in the non-recurrence group (37.5%, P=0.042). CONCLUSIONS: We failed to find any significant risk factors for FSGS recurrence after renal transplantation.
