Glycogen synthase kinase-3 and tumorigenesis
10.3760/cma.j.issn.1673-422X.2010.06.005
- VernacularTitle:糖原合成激酶-3β与肿瘤的发生发展
- Author:
Jian QIU
;
Yunfeng FU
- Publication Type:Journal Article
- Keywords:
Glycogen synthase kinase-3β;
Neoplasms
- From:
Journal of International Oncology
2010;37(6):416-419
- CountryChina
- Language:Chinese
-
Abstract:
It has recently been demonstrated that Glycogen synthase kinase-3β (GSK-3β) plays an important role in tumorigenesis through its regulation of tumor cell growth via a variety of mechanisms. In some tumors, activation of GSK-3β inhibits the growth of tumor cells whereas in other tumors, GSK-3β promotes tumor cells growth, meanwhile, GSK-3β may also regulate sensitivity of chemotherapy drugs to tumor cells,thus GSK-3β is likely to become a novel target for tumor therapy.
