A study on the expression of BCSG1, S100A4, VEGF in breast neoplasm

VernacularTitle:BCSG1,S100A4,VEGF在乳腺肿瘤中的表达
Author: Peihong SHEN ; Jie CHEN ; Zijun CHU ; Jie MA ; Qingxia FAN ; Yunhan ZHANG
Publication Type:Journal Article
Keywords: Breast neoplasms; Tumor invasiveness; Prognosis; BCSG1; S100A4; VEGF
From: Chinese Journal of General Surgery 2010;25(8):675-677
CountryChina
Language:Chinese
Abstract: Objective To study the expression of BCSG1 ,S100A4,VEGF in human breast cancer.Methods Immunohistochemistry technique SP method was used to examine breast fibroadenoma in 40 cases,breast invasive ductal carcinoma in 62 cases ( by armpit lymph node metastasis as 2 groups) and corresponding paratumor tissues in 48 cases. Results Among the 4 groups, there was significant difference ( P＜0.05 ) in the positive immunostaining rate of BCSG1 ,S100A4, VEGF. Conclusions In the breast invasive ductal carcinoma, the expression of BCSG1, S100A4 and VEGF increased. This suggested the invasive and metastasis ability of the neoplasm enhanced. The expression were in positive correlation with tumor pathology. Combined detection of BCSG1, S100A4, VEGF expression contributes to the early diagnosis and prognostic assessment of the carcinoma of the breast.