The prognosis of acinetobacter baumannii infection associated with drug resistance in the intensive care unit
10.3760/cma.j.issn.1008-6706.2010.13.010
- VernacularTitle:重症监护科鲍曼不动杆菌感染预后和耐药的关系
- Author:
Lei HUANG
;
Weixing ZHANG
- Publication Type:Journal Article
- Keywords:
Acinetobacter baumannii;
Prognosis;
Drug resistance;
Drug resistance,multiple
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(13):1748-1750
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the association between the prognosis of Acinetobacter baumannii infection and drug resistance among patients in the intensive care unit( ICU). Methods Eighty-four patients with Acine tobacter baumannii infection from February 2003 to April 2009 in Peking University Shenzhen Hospital ICU were retrospectively analyzed and divided into alive group(59 patients) and dead group(25 patients) by using 30-day mortality. The impact of drug resistant Acinetobacter baumannii on mortality was assessed by binary logistic regression. Results The mortality of patients with Acinetobacter baumannii infection was related to age, haematological malignancy, the Chanson Comorbidity Index, APACHEII score, multidrug-resistant Acinetobacter baumannii ( MDRAB) , carbapenem-resistant Acinetobacter baumannii (CRAB ) , septic shock and antimicrobial inappropriate therapy by univariate analysis( P < 0.05). Binary logistic regression revealed that CRAB( OR = 3. 360,95%CI: 1. 563 ～7.223,P< 0.05)and the Charison Comorbidity Index( OR = 1. 633,95% CI: 1. 201 ～2. 221 ,P <0.05) were independent risk factors. Conclusions The prognosis of Acinetobacter baumannii infection was closely correlated with drug resistance. The patients with CRAB infection had a higher mortality.
