Biological function of NDRG1 and its roles in tumorigenesis
10.3760/cma.j.issn.1673-422X.2010.06.001
- VernacularTitle:NDRG1基因的功能及与肿瘤的关系
- Author:
Zhenzhong FENG
- Publication Type:Journal Article
- Keywords:
NDRG1 gene;
Neoplasms;
Cell differentiation
- From:
Journal of International Oncology
2010;37(6):403-406
- CountryChina
- Language:Chinese
-
Abstract:
N-myc downstream-regulated gene 1 ( NDRG1 ), a member of the NDRG gene family, is a cell proliferation and differentiation related gene which usually express in various human tissues, especially higher in kidney, prostate and placenta. A variety of studies have reported that NDRG1 is correlated with cell proliferation and formation of periphery nerve sheath which might be regulated by hypoxia, anti-oncogene and metallic ion metabolism. Although NDRG1 gene expresses abnormally in tumor tissue, which is probably involved in tumorigenesis, development and metastasis, the exact role of NDRG1 in tumorigenesis is not clearly defined and further studies need to be done.
