The protective effect of the 27-β2 adrenergic receptor genetic polymorphisms in airway hyperreactivity
10.3760/cma.j.issn.1008-6706.2010.13.002
- VernacularTitle:β2-AR27位点基因多态性对气道高反应性的保护性作用研究
- Author:
Shaojie LI
;
Youping LIUFU
;
Man CHEN
;
Wuxing GONG
;
Xinran GUO
;
Yuqing WENG
;
Xiaomei HUANG
;
Qu ZHENG
;
Wei ZHENG
- Publication Type:Journal Article
- Keywords:
Asthma;
Receptors,adrenergic,beta-2;
Polymorphism,genetic
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(13):1731-1733
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the association between β2-AK 27 locus genetic polymorphisms and asthma, and the protective effect in airway hyperreactivity. Methods The allel polymerase chain reaction were used to determine β2-AR 27 locus genetic polymorphisms in 149 patients with cough variant asthma who have the airway hyperreactivity. To observe these people for two years in order to know the proportion of changed to typical asthma. And compare with 90 people in healthy group. Results (1) The distribution frequency of β2-AR 27 locus genetic polymorphisms is major in heterozygote (57 % ) , and the Glu/Glu homozygote has the least ( 20% ) , (2) There was a significant decrease in the frequency of Glu/Glu genotype in asthmatics compared with healthy group(9% VS 20% ) ,OR = 0.4(P<0.05) ,95% CI (0.2 ～0. 9) ,but there was no significant difference in the allele frequency of asthmatics compared with healthy group,(3)The frequency of Glu/Glu genotype in severe asthma was lower than stable asthma group(P<0. 05). Conclusion These results suggesteded that β2-AR 27 locus genetic polymorphisms is correlated with asthma,and the Glu27 could have the protective effect to the airway.
