Effects of mosapride and domperidone on the pulmonary infection of acute stroke patients lying in bed and with nasal feeding
10.3760/cma.j.issn.1673-4904.2010.22.003
- VernacularTitle:莫沙必利和多潘立酮对卧床鼻饲的急性脑卒中患者肺部感染的影响
- Author:
Haiyun ZHOU
;
Weidong JI
;
Chunjin XU
;
Yuhua SONG
;
Li LI
- Publication Type:Journal Article
- Keywords:
Domperidone;
Cerebral stroke;
Pulmonary infection;
Mosapride
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(22):7-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of mosapride and domperidone on the pulmonary infection of acute stroke patients lying in bed and with nasal feeding. Methods Eighty-nine acute stroke patients lying in bed and with nasal feeding were divided randomly into the treatment group (47 cases) and the control group (42 cases). The control group was treated routinely,and the treatment group was treated with mosapride 5 mg and domporidone 20 mg thrice a day for 4 weeks, besides routine therapy. The incidence rate of pulmonary infection, gastric residual volume (GRV) and the number of cases with gastric contents remaining after 3 hours of nasal feeding were studied. All data were analyzed statistically. Results In the treatment group, 13 cases had pulmonary infection,and the incidence rate was 27.66%(13/47). In the control group,25 cases had pulmonary infection,and the incidence rate was 59.52% (25/42). There was significant difference between the two groups (P < 0.01 ). Three hours after nasal feeding,24 cases with gastric contents remaining were discovered in the treatment group,and GRV was (50.80±15.38) ml. Two hundred and thirty-seven cases with gastric contents remaining were discovered in the control group, and GRV was (112.17±32.54) ml. Significance differences were also detected between the two groups (P<0.01). Conclusion As for the acute stroke patients lying in bed and with nasal feeding,mosapride and domperidone can remarkably cut down the pulmonary infection upon common treatment.
