Thioredoxin reductase and its inhibitors for cancer therapy

VernacularTitle:硫氧还蛋白还原酶及其抑制剂在肿瘤治疗中的研究进展
Author: Jiangfang FENG
Publication Type:Journal Article
Keywords: Thioredoxin reductase 1; Enzyme inhibitors; Neoplasms; Apoptosis
From: Journal of International Oncology 2010;37(6):429-432
CountryChina
Language:Chinese
Abstract: Thioredoxin reductase(TrxR) is an important component of thiol regulating system and contains a reactive and solvent accessible selenocysteine residue which is located on a flexible C-terminal arm of the protein and can combine various substrates and inhibitors. Many tumor cells have elevated TrxR levels and TrxR has also been shown to play a major role in drug resistance. A great number of effective natural and synthetic TrxR inhibitors are now availably possessing antitumor potential through induction of oxidative stress, cell cycle arrest and apoptosis. Inhibitors of TrxR may thus contribute to a successfully single, combinatory or adjuvant cancer therapy.