Significance of expressions of Ki67 and FHIT in adrenocortical tumor tissue
10.3760/cma.j.issn.1000-6699.2010.08.006
- VernacularTitle:Ki67和FHIT在肾上腺皮质肿瘤组织中的表达及相关性研究
- Author:
Decheng LU
;
Xuemei HUANG
;
Zuojie LUO
;
Jia ZHOU
;
Xinghuan LIANG
;
Jing XIAN
;
Wen CHEN
- Publication Type:Journal Article
- Keywords:
Adrenocortical tumor;
Immunohistochemistry;
Ki67;
FHIT
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(8):651-653
- CountryChina
- Language:Chinese
-
Abstract:
The expressions of Ki67 and FHIT were detected by immunohistochemical staining in 15 cases of adrenocortical carcinoma, 42 cases with adrenocortical adenoma,6 cases of adrenocortical hyperplasia, and 10 cases of normal adrenocortical tissue. The results showed that the highest expression of Ki67 and the lowest expression of FHIT were found in adrenocortical carcinoma. There were significant differences in the Ki67 and FHIT between adrenocortical adenoma and adrenocortical carcinoma ( both P < 0. 05 ). There existed negative correlation between the expressions of Ki67 and FHIT( r=-0. 712, P<0.05 ). Ki67 over-expression and loss of FHIT expression may be involved in the occurrence and development of adrenocortical carcinoma. It is suggested that combined detections of Ki67 and FHIT may have reference significance in the differentiation of adrenocortical adenoma from adrenocortical carcinoma.
