Deactivation of alveolar macrophages in neutropenic acute respiratory distress syndrome (ARDS) in children with hematologic malignancy
10.3760/cma.j.issn.1673-4912.2010.04.009
- VernacularTitle:儿童肿瘤化疗后粒细胞减少期并发ARDS肺泡巨噬细胞活性检测
- Author:
Juan QIAN
;
Liming JIANG
;
Biru LI
;
Li ZHAO
;
Yanwen YANG
;
Hong REN
;
Ying WANG
- Publication Type:Journal Article
- Keywords:
Alveolar macrophage;
Acute respiratory distress syndrome;
Neutropenia;
Human leukocyte antigen-DR
- From:
Chinese Pediatric Emergency Medicine
2010;17(4):312-314
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the alveolar macrophages (AM) activation in neutropenic ARDS in children with hematologic malignancy. Methods Thirteen patients of ARDS were prospectively enrolled into the study and divided into two groups,neutropenic (5 cases) and nonneutropenic (8 cases). Bronchoalveolar lavage fluid (BALF) samples were analyzed for differential and total cell counts, and alveolar activation marker expression (HLA-DR) was determined. Results In neutropenic patients,the BALF total cell count and the macrophage absolute count were significantly lower compared to those in nonneutropenic group ((62. 6 ±9. 6)/μl vs ( 124. 0 ± 6. 7)/μl,P ＜ 0. 01 and (40. 8 ±4. 3)/μl vs (67. 6 ± 10. 7)/μl,P ＜ 0. 01,respectively). As compared with the nonneutropenic group, the percentage of AM in neutropenic patients was significantly higher (65.9% ±9. 0% vs 54. 6% ± 8. 7% ,P ＜0. 05) ,the mean percentage of AM HLA-DR expression was significantly lower (35. 3% ± 5.8% vs 62. 2% ± 5. 8%, P ＜ 0. 01 ). Conclusion These results suggest an alveolar hypocellularity and a deactivation of AM in neutropenic ARDS in children with hematologic malignancy.
