Clinical observation of naloxone treatment in drowing children
10.3760/cma.j.issn.1673-4912.2010.04.013
- VernacularTitle:纳洛酮救治溺水儿童临床疗效观察
- Author:
Hongjun MIAO
;
Tao JIANG
;
Xuhua GE
;
Yong LIU
;
Shaodong ZHAO
;
Aidong CAI
- Publication Type:Journal Article
- Keywords:
Naloxone;
Drowing;
beta-Endorphin;
Children
- From:
Chinese Pediatric Emergency Medicine
2010;17(4):325-327
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effects and mechanism of naloxone treatment in drowing children.Methods A total of 97 drowing children were divided into treatment group(n=45)and control group(n=52)depending on whether the naloxone was administrated.General treatment was adopted in two groups.Treatment group Was given naloxone.The clinical effects were observed and the levels of betaendorphin(β-EP)in blood plasma were measured with radioimmunoassay(RIA)before and after treatment respectively.Results The total effective rate of treatment group(93.3%,42/45)Was significantly higher than that of control group(76.9%,40/52)(P＜0.05).As compared with that of control group(65.0%,26/40),nervous system disability rate in treatment group(33.3%,14/42)decreased significantly(P＜0.01).Continuous days of poor blood circulation,abnormal respiratory rhythm,convulsion and coma in treatment group were significantly shorter than those of control group respectively(P＜0.01).The level of β-EP was significantly lower in treatment group than that of control group(t=17.1,P＜0.01).Conclusion Clinical use of naloxone in the drowing children has curative result by reducing the level of blood plasma β-EP.
