Expression and significance of COX-2, VEGF in gestational trophoblastic tumor

VernacularTitle:环氧化酶-2和血管内皮细胞生长因子在妊娠滋养细胞肿瘤中的表达及意义
Author: Xiuyin YE ; Shujun CHEN ; Yingqing XIN ; Junda LIU
Publication Type:Journal Article
Keywords: Gestational trophoblastic disease; Cycloxygenase-2; Vascular endothelial growth factor; Immuno-histochemistry
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(15):2037-2039
CountryChina
Language:Chinese
Abstract: Objective To explore the role of COX-2 and VEGF in oncongensis and development of gestation-al trophoblastic disease,and evaluate prognosis of gestational trophoblastic tumor. Methods The expression of COX-2 and VEGF in normal chorion of early gestation and in gestational trophoblastic disease were detected by immunohis-tochemistry. Results In gestational trophoblastic tumor group,the positive rate of COX-2 and VEGF were significantly highter than that of normal chorion of early gestation group and the hydatidiform mole group respectively ( P < 0.01). There were positive correlation between COX-2 and VEGF in gestational trophoblastic tumor ( r = 0.795, P < 0.01). Conclusion The collaborative and over expression of COX-2 and VEGF were probably associated with the malignant change of trophoblastic cell,which suggest the worse prognosis of the gestational trophoblastic disease.