The application of inhaled nitric oxide in management of postoperative pulmonary hypertension
10.3760/cma.j.issn.1673-4912.2010.04.018
- VernacularTitle:吸入一氧化氮治疗先天性心脏病术后肺动脉高压的疗效观察
- Author:
Zhien ZHOU
;
Xiaosheng SUN
;
Shanxiu YAN
;
Jun FENG
;
Lunde HE
;
Daozhuang WANG
;
Shuozeng DENG
- Publication Type:Journal Article
- Keywords:
Congenital heart disease;
Nitric oxide;
Pulmonary hypertension
- From:
Chinese Pediatric Emergency Medicine
2010;17(4):336-337
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of inhaled nitric oxide (iNO) in management of postoperative pulmonary hypertension in the patients with congenital heart disease. Methods Thirty-two children with refractory pulmonary hypertension or pulmonary hypertensive crisis after open heart operations for congenital heart disease were treated with iNO. The changes of hemodynamics were observed. Results In iNO therapy group,the mean pulmonary artery pressure(mPAP) decreased from (38.0 ±3.2) mm Hg to (28.0 ±2.1) mm Hg,pulmonary vascular resistance (PVR) decreased from (62.2 ±6.7) kPa/(L·S) to (49.9 ±5.6) kPa/(L·S) ,PaO2/FiO2increased from (67.0 ±30. 1 ) mm Hg to (92. 6 ±25.0) mm Hg,and arterial oxygen saturation increased from 0. 78 ±0. 14 to 0. 84 ±0. 09 respectively. No toxic side effect was observed.Conclusion iNO is effective, safe to reduce pulmonary hypertension. It may play an important role in the treatment of postoperative pulmonary hypertension or pulmonary hypertensive crisis in the patients with congenital heart disease.
