The correlation among HBV DNA load, HBeAg/Anti-HBe and Alanine Aminotransferase in patients with chronic hepatitis B infection
10.3760/cma.j.issn.1008-6706.2010.14.003
- VernacularTitle:慢性HBV感染者血清HBV DNA载量与HBeAg/抗-HBe、ALT之间的关系
- Author:
Jun XU
;
Fang WANG
;
Fan YANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B,Chronic;
HBV DNA load;
HBeAg/Anti-HBe;
Alanine Aminotransferase
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(14):1877-1878
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship among HBV DNA load, HBeAg/Anti-HBe and ALT in patients with chronic hepatitis B infection. Methods HBV markers in 134 patients with chronic HBV infection were detected by ELISA,and patients were divided into group Ⅰ (HBeAg +/Anti-HBe-,43 patients) ,group Ⅱ (HBeAg-/Anti-HBe + ,69 patients)and group Ⅲ (HBeAg-/Anti-Hbe-,22 patients)according to the results of presence of HBeAg/Anti-HBe. HBV DNA load and ALT were tested respectively by fluorescence quantitative polymerase chain reaction technology and successive monitor reaction. Results Both the positive rate and the HBV DNA load quantification in group Ⅰ were higher than in group Ⅱ and Ⅲ (P＜0.01). Abnormality rate of ALT in HBV DNA positive patients was higher than the patients with HBV DNA negitive(P＜0.01). There was no relationship between HBV DNA load and ALT in HBV DNA positive patients. Conclusion There was a certain corelation among HBV DNA load, HBeAg/Anti-HBe and ALT,but the active degree of HBV replication could not to be assessed by HBeAg/Anti-HBe or ALT alone. It was necessary for the padient with chronic HBV infection to examine them together.
