Early postoperative enteral nutrition compared with parenteral nutrition after hepatectomy:A prospective randomized study
10.3760/cma.j.issn.1007-8118.2010.08.015
- VernacularTitle:肝切除术后早期肠内肠外营养支持的前瞻性随机研究
- Author:
Jiaming LAI
;
Lijian LIANG
;
Yunpeng HUA
;
Shi FANG
;
Yuantao HAO
;
Li HUANG
;
Baogang PENG
;
Dongming LI
- Publication Type:Journal Article
- Keywords:
Hepatectomy;
Enteral nutrition;
Parenteral nutrition
- From:
Chinese Journal of Hepatobiliary Surgery
2010;16(8):604-607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the impact of early enteral nutrition (EEN) compared with parenteral nutrition (PN) on patients after hepatectomy. Methods Seventy-eight patients undergoing liver resection were randomized prospectively into two groups: EEN group receiving early enteral nutrition (n=35) and PN group receiving parenteral nutrition (n=43). The patients in both groups received isocaloric and isonitrogenous nutritional formulas 24 h after operation and the formulas were stopped on postoperative day 7. The general conditions, liver function tests, clinical complications,and clinical nutritional variables at three time points that included preoperative phase, postoperative day 1 (POD 1) and postoperative day 8 (POD 8) were observed. Results No significant differences were found in length of hospital stay, liver function and clinical nutritional variables between the 2 groups. In the EEN group, the serum prealbumin level almost returned to the preoperative level on POD 8. The nutritional complication rate of the EEN group was increased significantly but it was milder than that of the PN group. The time of gut function recovery in the EEN group was shorter than that of the PN group. The costs of nutritional drugs showed a significant decrease in the EEN group.Conclusion Early enteral nutrition is safe, rational and effective in patients who have undergone hepatectomy. Early enteral nutrition is better than parenteral nutrition in promoting liver function recovery, liver protein synthesis, postoperative recovery of gut function and decreasing costs of nutritional drugs.
