Cognitive changes in amnestic mild cognitive impairment:a follow-up study
10.3760/cma.j.issn.1674-6554.2010.08.009
- VernacularTitle:遗忘型轻度认知功能损害认知特征的随访研究
- Author:
Yongmei SHI
;
Zhijun ZHANG
;
Hui YU
;
Yi WANG
;
Chunxian YUE
;
Yuhuan TENG
;
Feng BAI
;
Yonggui YUAN
;
Linglong DENG
- Publication Type:Journal Article
- Keywords:
Amnesia;
Mild cognitive impairment;
Dementia;
Neuropsychologic test
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(8):698-700
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate outcome and cognitive changes of amnestic mild cognitive impairment (aMCI) in a follow-up study. Methods A cross-sectional and longitudinal parallel cohort study design was conducted among 109 aMCI patients and 104 matched normal controls. Multi-dimension neuropsychologic tests were used to extensively assess the cognitive function. Results The scores of neuropsychologic tests in aMCI patients were significantly lower than those in the normal controls( all P＜0.01 ) ,with the largest impairment on 20minutes delayed recall of the auditory verbal memory test ( AVMT), which reflects episodic memory ( aMCI pa-tients :2.50 ± 1.48, normal controls :7.85 ± 1.59, Z = - 12.697, P ＜ 0.01 ); AD was diagnosed in 15 of the 69aMCI patients with a prevalence rate of 22% ,but none was converted to AD in the normal controls. The cognitivechanges of performance in AVMT, CDT, MMSE of the patients in aMCI group (( 3.77 ± 60.83 )%, (6.89 ±28.24) %, (6.13 ± 16.89) % respectively) were significantly poorer than those of the controls group(( - 10.75 ±27.46) %, ( - 5.23 ± 14.05 ) %, ( - 1.11 ± 8.26 ) % respectively) ( all P ＜ 0.05 ). At baseline, demented aMCIperformed poorer in AVMT, CFT, TMT, SDMT, CDT, MMSE when compared to stable. During the follow-up, demented aMCI groups performed significantly poorer than did stable subjects in AVMT, CFT, DST, VFT, SDMT,MMSE ( all P ＜ 0.05 ). Conclusion aMCI is a prodromal period of AD and characterized by episodic memory impairment. The neuropsychologic test is a predictive factor for aMCI to develop AD.
