Preoperative and postoperative prognostic indicators of recurrence of hepatocellular carcinoma following liver transplantation
10.3760/cma.j.issn.1673-4203.2010.08.018
- VernacularTitle:肝细胞癌移植术后肿瘤复发的评估、预防和治疗
- Author:
Di WU
;
Hong ZHENG
- Publication Type:Journal Article
- Keywords:
Hepatocellular Carcinoma;
Liver transplantation;
Recurrent
- From:
International Journal of Surgery
2010;37(8):557-561
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation is a valid treatment option for select patients with Hepatocellular Carcinoma HCC and end-stage liver disease. However, in approximately 20% of patients, recurrent HCC is the rate-limiting factor for longterm survival. Despite identification of clinical parameters that may stratify patients at high risk and exhaustive preoperative staging, cancer recurrence is likely the result of microscopic extrahepatic disease. With a desperate donor organ shortage, locoregional ablation techniques and resection are being employed in patients on the waiting list to serve as a bridge to OLT. Further more, some have advocated aggressive surgical resection of isolated metastasis in both the liver and extrahepatic viscera. Whether these creative strategies confer a survival advantage is unknown, requiring longterm follow-up to determine their efficacy.
