Multifocal papillary thyroid carcinoma

Lin Lin; Xiangqian Zheng; Lei Liu; Yigong LI; Yan Zhang; Ming Gao

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Multifocal papillary thyroid carcinoma

VernacularTitle:多灶性甲状腺乳头状癌的生物学特性及治疗分析
Author: Lin LIN ; Xiangqian ZHENG ; Lei LIU ; Yigong LI ; Yan ZHANG ; Ming GAO
Publication Type:Journal Article
Keywords: Thyroid neoplasms; Thyroidectomy; Neck dissection; Papillary carcinoma
From: Chinese Journal of General Surgery 2010;25(8):621-623
CountryChina
Language:Chinese
Abstract: Objective To investigate the biological characteristics and management of multifocal papillary thyroid carcinoma. Methods Clinical data of 86 patients who underwent thyroidectomy and were pathologically diagnosed as progressive multifocal papillary thyroid carcinoma from 1995 to 1997 in Tianjin Cancer Hospital were retrospectively analyzed. Results There were 86 cases of multifocal papillary thyroid carcinoma, accounting for 23.4% of all papillary thyroid carcinoma of the same period. In the 86 cases of multifocal papillary thyroid carcinoma, there was unilateral in 12 cases and bilateral in 74 cases; cervical lymph node metastasis in 51 cases ( 59. 3% ); combined microcarcinoma of 46 cases ( 53.5% );Hashimoto's thyroiditis was concomitant in 23 cases (26.7%); local invasion was found in 19 cases (22. 1% ); distant metastasis occurred in 1 case ( 1.2% ); 10-year survival rate was 95.3%. American Joint Committee on Cancer ( AJCC ) stage was associated with prognosis significantly ( x2 = 63. 395, P =0.000). Conclusions Multifocal papillary thyroid carcinoma often occurs bilaterally, concomitant microcarcinoma and Hashimoto's thyroiditis is common with a comparatively favorable prognosis. AJCC stage is still the best prognostic factor.